The five-day International Conference on “Innovations and Challenges in Science and Technology” took place from December 19th to 23rd, 2019. Dr. Jan Mithran Kumar Somasundrum, Scientist at the National Center for Genetic Engineering and Biotechnology, Thailand, was a key guest, with twelve distinguished speakers and ten session chairpersons. Organized with Visvesvaraya Technological University and sponsored by the Indian Society for Technical Education, the conference featured 207 abstracts and had 152 participants.